Everything about ceesdekker

Rotary motion of DNA rotors on nanopores. Major row: raw video with the Cy5 channel of each rotor. Center row: corresponding single-particle localization success of equally finishes of your DNA rotors. The placement of the present frame is marked as orange and blue dots, as well as trajectory of the 10 frames right before the current body is shown as stable lines.

1996, very first mesoscopic demand density waves gadgets; and initially electrical measurements on a single steel nanocluster involving nanoelectrodes

Dynamics of initiation, termination and reinitiation of DNA translocation with the motor protein EcoR124I

Given that 2000, Dekker has shifted the leading concentrate of his operate to biophysics exactly where he reports the Attributes of single biomolecules and cells using the instruments of nanotechnology. This alteration of discipline was pushed by his fascination for that remarkable working of biological molecular constructions, together with by the lengthy-time period standpoint that many fascinating discoveries could be anticipated With this industry.[five] Present-day strains of research in his biophysics group are within the areas of:[6]

2012, discovery that nucleoid occlusion underlies the accuracy of bacterial mobile division; and very first at any time examine of the dynamics DNA supercoils and the invention of supercoil hopping

The coiled-coil of the human Rad50 DNA maintenance protein is made up of particular segments of amplified versatility

We form bacteria into types that deviate from their normal phenotype. Particularly, I'll present our capability to shape live ceesdekker.net E. coli microbes into novel styles for example rectangles, squares, triangles and circles.

Dynamic ParB–DNA interactions initiate and maintain a partition condensate for bacterial chromosome segregation

The rotors harness Power from the nanoscale drinking water and ion movement that is created by a static chemical or electrochemical likely gradient within the nanopore, which are founded by way of a salt gradient or applied voltage, respectively. These synthetic nanoengines self-organize and work autonomously in physiological problems, suggesting methods to developing Vitality-transducing motors at nanoscale interfaces.

Dekker started his exploration on solitary carbon nanotubes in 1993 when he set up a completely new line of exploration to study electrical transportation by way of single natural and organic molecules amongst nanoelectrodes. In 1996 a breakthrough was realized with carbon nanotubes. This was obtained in the collaboration Using the team of Nobel laureate Richard Smalley. STM and nanolithography tactics were utilized to exhibit that these nanotubes are quantum wires at The one-molecule degree, with outstanding Bodily properties.

Considering the fact that 2000 he moved to solitary-molecule biophysics and nanobiology, with study from experiments of DNA loop extrusion and supercoiling to DNA translocation by way of nanopores. Much more a short while ago his exploration has focused on finding out chromatin structure and mobile division with germs on chip, though he is additionally seeking to eventually build synthetic cells from The underside up.

Nanoscientist Cees Dekker is surely an amiable and flamboyant man who seems Significantly younger in comparison to the 62 decades he in fact is – fashionable Eyeglasses, psychedelic shirt, engaging smile – although not a single to squander time. He will take his time, but not more than needed.

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Illustration (2) of bending configurations in 3D simulations of DNA rods on nanopores. A part of the membrane is revealed in grey, the rim on the pore is highlighted in red, plus a 3D rendering of your motion on the DNA rod is exhibited.